ParkinsonCanadaV1, Main, Exploration, bibRecord, 000454

A descending dopamine pathway conserved from basal vertebrates to mammals

Identifieur interne : 000454 ( Main/Exploration ); précédent : 000453; suivant : 000455

A descending dopamine pathway conserved from basal vertebrates to mammals

Auteurs : Dimitri Ryczko [Canada] ; Jackson J. Cone ; Michael H. Alpert ; Laurent Goetz [Canada] ; François Auclair [Canada] ; Catherine Dubé [Canada] ; Martin Parent [Canada] ; Mitchell F. Roitman ; Simon Alford ; Réjean Dubuc [Canada]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2016.

RBID : PMC:4855556

English descriptors

KwdEn :
- Aged, Animals, Biological Evolution, Brain Stem (physiology), Corpus Striatum (physiology), Dopamine, Dopaminergic Neurons (physiology), Female, Humans, Lampreys (physiology), Locomotion (physiology), Male, Motor Cortex (physiology), Pedunculopontine Tegmental Nucleus (physiology), Rats, Rats, Sprague-Dawley, Rats, Transgenic, Urodela (physiology).
MESH :
- chemical : Dopamine.
- physiology : Brain Stem, Corpus Striatum, Dopaminergic Neurons, Lampreys, Locomotion, Motor Cortex, Pedunculopontine Tegmental Nucleus, Urodela.
- Aged, Animals, Biological Evolution, Female, Humans, Male, Rats, Rats, Sprague-Dawley, Rats, Transgenic.

Abstract

Significance

In vertebrates, the contribution of dopamine neurons to locomotor control is traditionally attributed to their ascending projections to the basal ganglia that, in turn, project down to brainstem locomotor networks. We recently discovered in lampreys that brainstem networks receive a direct descending dopaminergic input that increases locomotor output. Here, we show that this descending dopaminergic pathway is conserved in higher vertebrates. We found that dopamine is released in salamander brainstem locomotor networks, together with reticulospinal cell activation, known to trigger locomotion. Dopamine is released in rat brainstem locomotor networks, and amphetamine potentiates dopamine release in vivo. Finally, brainstem locomotor networks in human tissue contain dopaminergic terminals. Our findings have important implications for understanding the locomotor role of dopamine in vertebrates.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855556

DOI: 10.1073/pnas.1600684113
PubMed: 27071118
PubMed Central: 4855556

Affiliations:

Canada

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A descending dopamine pathway conserved from basal vertebrates to mammals</title>
<author><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cone, Jackson J" sort="Cone, Jackson J" uniqKey="Cone J" first="Jackson J." last="Cone">Jackson J. Cone</name>
<affiliation><nlm:aff id="aff2">Department of Psychology,<institution>University of Illinois</institution>
, Chicago,<addr-line>IL</addr-line>
 60607;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alpert, Michael H" sort="Alpert, Michael H" uniqKey="Alpert M" first="Michael H." last="Alpert">Michael H. Alpert</name>
<affiliation><nlm:aff id="aff3">Department of Biological Sciences,<institution>University of Illinois at Chicago</institution>
,<country>Chicago</country>
,<addr-line>IL</addr-line>
 60607;</nlm:aff>
<wicri:noCountry code="nlm country">Chicago</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec,<institution>Université Laval</institution>
, Quebec, QC,<country>Canada</country>
 G1J 2G3;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auclair, Francois" sort="Auclair, Francois" uniqKey="Auclair F" first="François" last="Auclair">François Auclair</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dube, Catherine" sort="Dube, Catherine" uniqKey="Dube C" first="Catherine" last="Dubé">Catherine Dubé</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec,<institution>Université Laval</institution>
, Quebec, QC,<country>Canada</country>
 G1J 2G3;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roitman, Mitchell F" sort="Roitman, Mitchell F" uniqKey="Roitman M" first="Mitchell F." last="Roitman">Mitchell F. Roitman</name>
<affiliation><nlm:aff id="aff2">Department of Psychology,<institution>University of Illinois</institution>
, Chicago,<addr-line>IL</addr-line>
 60607;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alford, Simon" sort="Alford, Simon" uniqKey="Alford S" first="Simon" last="Alford">Simon Alford</name>
<affiliation><nlm:aff id="aff3">Department of Biological Sciences,<institution>University of Illinois at Chicago</institution>
,<country>Chicago</country>
,<addr-line>IL</addr-line>
 60607;</nlm:aff>
<wicri:noCountry code="nlm country">Chicago</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Département des Sciences de l’Activité Physique,<institution>Université du Québec à Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3P8</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27071118</idno>
<idno type="pmc">4855556</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855556</idno>
<idno type="RBID">PMC:4855556</idno>
<idno type="doi">10.1073/pnas.1600684113</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000129</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000129</idno>
<idno type="wicri:Area/Pmc/Curation">000129</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000129</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000166</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000166</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000248</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000248</idno>
<idno type="wicri:Area/PubMed/Curation">000248</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000248</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000248</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000248</idno>
<idno type="wicri:Area/Ncbi/Merge">001F34</idno>
<idno type="wicri:Area/Ncbi/Curation">001F34</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F34</idno>
<idno type="wicri:doubleKey">0027-8424:2016:Ryczko D:a:descending:dopamine</idno>
<idno type="wicri:Area/Main/Merge">000455</idno>
<idno type="wicri:Area/Main/Curation">000454</idno>
<idno type="wicri:Area/Main/Exploration">000454</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A descending dopamine pathway conserved from basal vertebrates to mammals</title>
<author><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cone, Jackson J" sort="Cone, Jackson J" uniqKey="Cone J" first="Jackson J." last="Cone">Jackson J. Cone</name>
<affiliation><nlm:aff id="aff2">Department of Psychology,<institution>University of Illinois</institution>
, Chicago,<addr-line>IL</addr-line>
 60607;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alpert, Michael H" sort="Alpert, Michael H" uniqKey="Alpert M" first="Michael H." last="Alpert">Michael H. Alpert</name>
<affiliation><nlm:aff id="aff3">Department of Biological Sciences,<institution>University of Illinois at Chicago</institution>
,<country>Chicago</country>
,<addr-line>IL</addr-line>
 60607;</nlm:aff>
<wicri:noCountry code="nlm country">Chicago</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec,<institution>Université Laval</institution>
, Quebec, QC,<country>Canada</country>
 G1J 2G3;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auclair, Francois" sort="Auclair, Francois" uniqKey="Auclair F" first="François" last="Auclair">François Auclair</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dube, Catherine" sort="Dube, Catherine" uniqKey="Dube C" first="Catherine" last="Dubé">Catherine Dubé</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre de Recherche de l’Institut Universitaire en Santé Mentale de Québec,<institution>Université Laval</institution>
, Quebec, QC,<country>Canada</country>
 G1J 2G3;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Roitman, Mitchell F" sort="Roitman, Mitchell F" uniqKey="Roitman M" first="Mitchell F." last="Roitman">Mitchell F. Roitman</name>
<affiliation><nlm:aff id="aff2">Department of Psychology,<institution>University of Illinois</institution>
, Chicago,<addr-line>IL</addr-line>
 60607;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alford, Simon" sort="Alford, Simon" uniqKey="Alford S" first="Simon" last="Alford">Simon Alford</name>
<affiliation><nlm:aff id="aff3">Department of Biological Sciences,<institution>University of Illinois at Chicago</institution>
,<country>Chicago</country>
,<addr-line>IL</addr-line>
 60607;</nlm:aff>
<wicri:noCountry code="nlm country">Chicago</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Groupe de Recherche sur le Système Nerveux Central, Département de Neurosciences,<institution>Université de Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3J7;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Département des Sciences de l’Activité Physique,<institution>Université du Québec à Montréal</institution>
, Montreal, QC,<country>Canada</country>
 H3C 3P8</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Brain Stem (physiology)</term>
<term>Corpus Striatum (physiology)</term>
<term>Dopamine</term>
<term>Dopaminergic Neurons (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Lampreys (physiology)</term>
<term>Locomotion (physiology)</term>
<term>Male</term>
<term>Motor Cortex (physiology)</term>
<term>Pedunculopontine Tegmental Nucleus (physiology)</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Rats, Transgenic</term>
<term>Urodela (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Brain Stem</term>
<term>Corpus Striatum</term>
<term>Dopaminergic Neurons</term>
<term>Lampreys</term>
<term>Locomotion</term>
<term>Motor Cortex</term>
<term>Pedunculopontine Tegmental Nucleus</term>
<term>Urodela</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Animals</term>
<term>Biological Evolution</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
<term>Rats, Transgenic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>In vertebrates, the contribution of dopamine neurons to locomotor control is traditionally attributed to their ascending projections to the basal ganglia that, in turn, project down to brainstem locomotor networks. We recently discovered in lampreys that brainstem networks receive a direct descending dopaminergic input that increases locomotor output. Here, we show that this descending dopaminergic pathway is conserved in higher vertebrates. We found that dopamine is released in salamander brainstem locomotor networks, together with reticulospinal cell activation, known to trigger locomotion. Dopamine is released in rat brainstem locomotor networks, and amphetamine potentiates dopamine release in vivo. Finally, brainstem locomotor networks in human tissue contain dopaminergic terminals. Our findings have important implications for understanding the locomotor role of dopamine in vertebrates.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Alford, Simon" sort="Alford, Simon" uniqKey="Alford S" first="Simon" last="Alford">Simon Alford</name>
<name sortKey="Alpert, Michael H" sort="Alpert, Michael H" uniqKey="Alpert M" first="Michael H." last="Alpert">Michael H. Alpert</name>
<name sortKey="Cone, Jackson J" sort="Cone, Jackson J" uniqKey="Cone J" first="Jackson J." last="Cone">Jackson J. Cone</name>
<name sortKey="Roitman, Mitchell F" sort="Roitman, Mitchell F" uniqKey="Roitman M" first="Mitchell F." last="Roitman">Mitchell F. Roitman</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name>
</noRegion>
<name sortKey="Auclair, Francois" sort="Auclair, Francois" uniqKey="Auclair F" first="François" last="Auclair">François Auclair</name>
<name sortKey="Dube, Catherine" sort="Dube, Catherine" uniqKey="Dube C" first="Catherine" last="Dubé">Catherine Dubé</name>
<name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name>
<name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name>
<name sortKey="Goetz, Laurent" sort="Goetz, Laurent" uniqKey="Goetz L" first="Laurent" last="Goetz">Laurent Goetz</name>
<name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000454 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000454 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4855556
   |texte=   A descending dopamine pathway conserved from basal vertebrates to mammals
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27071118" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

A descending dopamine pathway conserved from basal vertebrates to mammals

A descending dopamine pathway conserved from basal vertebrates to mammals

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.